Synthesis and binding affinity of neuropeptide Y at opiate receptors

James J Kiddle; Heather J McCreery; Sonia Soles

doi:10.1016/s0960-894x(03)00082-9

Synthesis and binding affinity of neuropeptide Y at opiate receptors

Bioorg Med Chem Lett. 2003 Mar 24;13(6):1029-31. doi: 10.1016/s0960-894x(03)00082-9.

Authors

James J Kiddle¹, Heather J McCreery, Sonia Soles

Affiliation

¹ Department of Chemistry, University of North Carolina at Wilmington, 601 South College Road, Wilmington, NC 28403, USA. james.kiddle@wmich.edu

PMID: 12643904
DOI: 10.1016/s0960-894x(03)00082-9

Abstract

Neuropeptide Y and several metabolic fragments were synthesized and evaluated for binding affinity at non-selective opiate receptors. Neuropeptide Y and several C-terminal fragments were shown to bind to non-selective opiate receptors with an affinity similar to that of Leu-enkephalin.

MeSH terms

Amino Acid Sequence
Appetite Stimulants / chemical synthesis
Appetite Stimulants / metabolism*
Enkephalin, Leucine / metabolism
Humans
Molecular Sequence Data
Neuropeptide Y / analogs & derivatives*
Neuropeptide Y / chemical synthesis
Neuropeptide Y / metabolism*
Peptide Fragments / chemical synthesis
Peptide Fragments / pharmacology
Receptors, Opioid / metabolism*

Substances

Appetite Stimulants
Neuropeptide Y
Peptide Fragments
Receptors, Opioid
Enkephalin, Leucine